Origin of the 1918 pandemic H1N1 influenza A virus as studied by codon usage patterns and phylogenetic analysis.
Identifieur interne : 000C28 ( Main/Exploration ); précédent : 000C27; suivant : 000C29Origin of the 1918 pandemic H1N1 influenza A virus as studied by codon usage patterns and phylogenetic analysis.
Auteurs : Darisuren Anhlan [Allemagne] ; Norbert Grundmann ; Wojciech Makalowski ; Stephan Ludwig ; Christoph ScholtissekSource :
- RNA (New York, N.Y.) [ 1469-9001 ] ; 2011.
Descripteurs français
- KwdFr :
- Amorces ADN (), Amorces ADN (génétique), Animaux, Codon (), Codon (génétique), Grippe humaine (génétique), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Infections à Orthomyxoviridae (génétique), Infections à Orthomyxoviridae (virologie), Infections à Orthomyxoviridae (épidémiologie), Oiseaux, Pandémies, Phylogénie, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Évolution moléculaire.
- MESH :
- génétique : Amorces ADN, Codon, Grippe humaine, Infections à Orthomyxoviridae, Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- épidémiologie : Grippe humaine, Infections à Orthomyxoviridae.
- Amorces ADN, Animaux, Codon, Humains, Oiseaux, Pandémies, Phylogénie, Sous-type H1N1 du virus de la grippe A, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Birds, Codon (chemistry), Codon (genetics), DNA Primers (chemistry), DNA Primers (genetics), Evolution, Molecular, Humans, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (virology), Orthomyxoviridae Infections (epidemiology), Orthomyxoviridae Infections (genetics), Orthomyxoviridae Infections (virology), Pandemics, Phylogeny.
- MESH :
- chemical , chemistry : Codon, DNA Primers.
- chemical , genetics : Codon, DNA Primers.
- classification : Influenza A Virus, H1N1 Subtype.
- epidemiology : Influenza, Human, Orthomyxoviridae Infections.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza, Human, Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Birds, Evolution, Molecular, Humans, Pandemics, Phylogeny.
Abstract
The pandemic of 1918 was caused by an H1N1 influenza A virus, which is a negative strand RNA virus; however, little is known about the nature of its direct ancestral strains. Here we applied a broad genetic and phylogenetic analysis of a wide range of influenza virus genes, in particular the PB1 gene, to gain information about the phylogenetic relatedness of the 1918 H1N1 virus. We compared the RNA genome of the 1918 strain to many other influenza strains of different origin by several means, including relative synonymous codon usage (RSCU), effective number of codons (ENC), and phylogenetic relationship. We found that the PB1 gene of the 1918 pandemic virus had ENC values similar to the H1N1 classical swine and human viruses, but different ENC values from avian as well as H2N2 and H3N2 human viruses. Also, according to the RSCU of the PB1 gene, the 1918 virus grouped with all human isolates and "classical" swine H1N1 viruses. The phylogenetic studies of all eight RNA gene segments of influenza A viruses may indicate that the 1918 pandemic strain originated from a H1N1 swine virus, which itself might be derived from a H1N1 avian precursor, which was separated from the bulk of other avian viruses in toto a long time ago. The high stability of the RSCU pattern of the PB1 gene indicated that the integrity of RNA structure is more important for influenza virus evolution than previously thought.
DOI: 10.1261/rna.2395211
PubMed: 21068184
Affiliations:
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Le document en format XML
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Ludwig</name></author><author><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name></author></analytic><series><title level="j">RNA (New York, N.Y.)</title><idno type="eISSN">1469-9001</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Birds</term><term>Codon (chemistry)</term><term>Codon (genetics)</term><term>DNA Primers (chemistry)</term><term>DNA Primers (genetics)</term><term>Evolution, Molecular</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (classification)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (genetics)</term><term>Influenza, Human (virology)</term><term>Orthomyxoviridae Infections 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Here we applied a broad genetic and phylogenetic analysis of a wide range of influenza virus genes, in particular the PB1 gene, to gain information about the phylogenetic relatedness of the 1918 H1N1 virus. We compared the RNA genome of the 1918 strain to many other influenza strains of different origin by several means, including relative synonymous codon usage (RSCU), effective number of codons (ENC), and phylogenetic relationship. We found that the PB1 gene of the 1918 pandemic virus had ENC values similar to the H1N1 classical swine and human viruses, but different ENC values from avian as well as H2N2 and H3N2 human viruses. Also, according to the RSCU of the PB1 gene, the 1918 virus grouped with all human isolates and "classical" swine H1N1 viruses. The phylogenetic studies of all eight RNA gene segments of influenza A viruses may indicate that the 1918 pandemic strain originated from a H1N1 swine virus, which itself might be derived from a H1N1 avian precursor, which was separated from the bulk of other avian viruses in toto a long time ago. The high stability of the RSCU pattern of the PB1 gene indicated that the integrity of RNA structure is more important for influenza virus evolution than previously thought.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Münster</li></settlement></list><tree><noCountry><name sortKey="Grundmann, Norbert" sort="Grundmann, Norbert" uniqKey="Grundmann N" first="Norbert" last="Grundmann">Norbert Grundmann</name><name sortKey="Ludwig, Stephan" sort="Ludwig, Stephan" uniqKey="Ludwig S" first="Stephan" last="Ludwig">Stephan Ludwig</name><name sortKey="Makalowski, Wojciech" sort="Makalowski, Wojciech" uniqKey="Makalowski W" first="Wojciech" last="Makalowski">Wojciech Makalowski</name><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Anhlan, Darisuren" sort="Anhlan, Darisuren" uniqKey="Anhlan D" first="Darisuren" last="Anhlan">Darisuren Anhlan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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